Greenville is in a central relative location, being equidistant from Raleigh to the west and the Outer Banks to the east. It is also approximately midway between the North Carolina-Virginia border and the North Carolina-South Carolina border.
By plane
You can fly in from Charlotte to the Pitt-Greenville Airport in town or fly into the Raleigh-Durham International Airport and use a rental car. US Airways Express operates a charter flight to and from Greenville and the airline's regional hub in Charlotte.
By car
From Raleigh, NC, use US Routes 64 East, 264 East, and 13 North to get into town. Charlotte Douglas International Airport is considerably further away, but Greenville can be reached from there via I-277 North, I-77 North, I-85 North, I-40 East and from that point, one uses the routes used by going from Raleigh to Greenville mentioned earlier. From I-95 North or South, use US 264 East to reach Greenville.